THOSE PESKY GENES AGAIN

High African prostate cancer risk tied to DNA

A team led by Harvard researchers has found dramatic genetic links to prostate cancer that appear to underlie many of the cases and help explain the higher occurrence of the disease among African-American men. The scientists said yesterday that they have identified a set of changes in human DNA that are common in the American population and that, together, can increase the risk of the disease by more than five times. These changes may be responsible for up to two-thirds of African-American cases and one-third of the cases among Caucasian-Americans, according to a report in the journal Nature Genetics. The discovery may eventually allow doctors to improve screening, a strategy that has had an impact on the disease, by identifying high-risk people to be tested at an earlier age. And it could someday lead to better treatments for the second-leading cancer killer of men...

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